A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus

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Lana, D.; 2015; A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus. Firenze, Firenze University Press.


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A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus

Molecular and cellular alterations underlying memory impairments in animal models of neurodegeneration

Daniele Lana
University of Florence, Italy - ORCID: 0000-0002-5193-0019

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DOI: 10.36253/978-88-6655-941-2 Series: Premio Tesi di Dottorato ISSN 2612-8039 (print) - ISSN 2612-8020 (online)

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© 2015 Author(s)
Published by Firenze University Press

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Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroin ammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad.

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Publication year: 2015

Price: 12,90 €

Pages: 136

ISSN print: 2612-8039

ISBN: 978-88-6655-940-5

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Publication year: 2015

Pages: 136

ISSN online: 2612-8020

e-ISBN: 978-88-6655-941-2

DOI: 10.36253/978-88-6655-941-2

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© 2015 Author(s)
Content licence CC BY 4.0
Metadata licence CC0 1.0

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Publication year: 2015

ISSN online: 2612-8020

e-ISBN: 978-88-9273-311-4

DOI: 10.36253/978-88-6655-941-2

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© 2015 Author(s)
Content licence CC BY 4.0
Metadata licence CC0 1.0

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