Molecular imaging in Parkinson's disease

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Polito, C.; 2011; Molecular imaging in Parkinson's disease. Firenze, Firenze University Press.


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Molecular imaging in Parkinson's disease

Cristina Polito
University of Florence, Italy - ORCID: 0000-0001-7509-5575

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DOI: 10.36253/978-88-6655-041-9 Series: Premio Tesi di Dottorato ISSN 2612-8039 (print) - ISSN 2612-8020 (online)

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© 2011 Author(s)
Published by Firenze University Press

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The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.

The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.

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Publication year: 2011

Price: 9,90 €

Pages: 68

ISSN print: 2612-8039

ISBN: 978-88-6655-037-2

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Publication year: 2011

Pages: 68

ISSN online: 2612-8020

e-ISBN: 978-88-6655-041-9

DOI: 10.36253/978-88-6655-041-9

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© 2011 Author(s)
Content licence CC BY-ND 3.0 IT
Metadata licence CC0 1.0

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Publication year: 2011

ISSN online: 2612-8020

e-ISBN: 978-88-9273-645-0

DOI: 10.36253/978-88-6655-041-9

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© 2011 Author(s)
Content licence CC BY-ND 3.0 IT
Metadata licence CC0 1.0

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