Structural and functional aspects of membranes

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Evangelisti, E.; 2013; Structural and functional aspects of membranes. Firenze, Firenze University Press.


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Structural and functional aspects of membranes

The involvement of lipid rafts in Alzheimer’s disease pathogenesis. The interplay between protein oligomers and plasma membrane physicochemical features in determining cytotoxicity
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DOI: 10.36253/978-88-6655-445-5 Series: Premio Tesi di Dottorato ISSN 2612-8039 (print) - ISSN 2612-8020 (online)

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© 2013 Author(s)
Published by Firenze University Press

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Alzheimer’s disease (AD) is a common form of dementia characterized by the formation of extracellular senile plaques composed of aggregated amyloid peptide (Aβ). The present studies provide evidence that: cell resistance to amyloid toxicity is related to lipid raft cholesterol content. Cholesterol and GM1, affect the susceptibility of Familial Alzheimer’s Disease (FAD) broblasts to Aβ42 oligomers in opposite ways, by modulating amyloid binding to lipid rafts and its subsequent toxic effects. The degree of toxicity of the oligomeric species results from a complex interplay between the structural and physicochemical features of both the oligomers and the cellular membrane. Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity.

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Publication year: 2013

Price: 10,90 €

Pages: 152

ISSN print: 2612-8039

ISBN: 978-88-6655-444-8

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PDF

Publication year: 2013

Pages: 152

ISSN online: 2612-8020

e-ISBN: 978-88-6655-445-5

DOI: 10.36253/978-88-6655-445-5

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© 2013 Author(s)
Content licence CC BY-ND 3.0 IT
Metadata licence CC0 1.0

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Publication year: 2013

ISSN online: 2612-8020

e-ISBN: 978-88-9273-471-5

DOI: 10.36253/978-88-6655-445-5

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© 2013 Author(s)
Content licence CC BY-ND 3.0 IT
Metadata licence CC0 1.0