Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

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Martinelli, S.; 2017; Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms. Firenze, Firenze University Press.


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Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms

Serena Martinelli
University of Florence, Italy

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DOI: 10.36253/978-88-6453-565-4 Series: Premio Tesi di Dottorato ISSN 2612-8039 (print) - ISSN 2612-8020 (online)

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© 2017 Author(s)
Published by Firenze University Press

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A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms

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Publication year: 2017

Price: 9,90 €

Pages: 80

ISSN print: 2612-8039

ISBN: 978-88-6453-564-7

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Publication year: 2017

Pages: 80

ISSN online: 2612-8020

e-ISBN: 978-88-6453-565-4

DOI: 10.36253/978-88-6453-565-4

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© 2017 Author(s)
Content licence CC BY 4.0
Metadata licence CC0 1.0

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Publication year: 2017

ISSN online: 2612-8020

e-ISBN: 978-88-9273-168-4

DOI: 10.36253/978-88-6453-565-4

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© 2017 Author(s)
Content licence CC BY 4.0
Metadata licence CC0 1.0